DST INSPIRE Faculty Fellow uncovers regulatory role of proteins in neuronal development, paving way for modifying treatment protocols
Dr. Priyanka Dutta, Inspire Faculty Fellow, has recently uncovered the mechanism by which a protein called Formin-2 disrupts neural connectivity and could result in developmental defects associated with intellectual disability and deficits in learning and memory.
Establishment of a functional neuronal circuit is essential for proper functioning of the nervous system. To understand the neuronal coordination of an organism, it is important to comprehend how the underlying cytoskeleton or the complex network of interlinking protein filaments in the cytoplasm of cells assemble and function assisted by its regulatory proteins. The errors in neuronal connectivity are central to genetic mutations of these proteins, which lead to detrimental developmental defects.