Detection of cholesterol

Study reports that a sensor region on human serotonin receptor that can detect cholesterol

September 15, 2021
The Scitech

Cells communicate with each other via receptor proteins expressed on the cell membranes.  Many drugs target these receptor proteins to alter cell’s functioning and physiology. However, the latest study from Prof Amitabha Chattopadhyay’s lab at CSIR-Centre for Cellular and Molecular Biology (CCMB) makes a case for accounting for the lipid environment that surrounds the receptor proteins, while designing drugs acting on the latter. The lab had earlier found that the serotonin receptors are sensitive to cholesterol surrounding them. In the new study published in Science Advances, they report a sensor region on human serotonin1A receptor that can detect cholesterol.